B cell clonal expansion and convergent antibody responses to SARS-CoV-2.
Identifieur interne : 000783 ( Main/Exploration ); précédent : 000782; suivant : 000784B cell clonal expansion and convergent antibody responses to SARS-CoV-2.
Auteurs : Sandra C A. Nielsen [États-Unis] ; Fan Yang [États-Unis] ; Ramona A. Hoh [États-Unis] ; Katherine J L. Jackson ; Katharina Roeltgen [États-Unis] ; Ji-Yeun Lee [États-Unis] ; Arjun Rustagi [États-Unis] ; Angela J. Rogers [États-Unis] ; Abigail E. Powell [États-Unis] ; Peter S. Kim [États-Unis] ; Taia T. Wang [États-Unis] ; Benjamin Pinsky [États-Unis] ; Catherine A. Blish [États-Unis] ; Scott D. Boyd [États-Unis]Source :
- Research square ; 2020.
Abstract
During virus infection B cells are critical for the production of antibodies and protective immunity. Establishment of a diverse antibody repertoire occurs by rearrangement of germline DNA at the immunoglobulin heavy and light chain loci to encode the membrane-bound form of antibodies, the B cell antigen receptor. Little is known about the B cells and antigen receptors stimulated by the novel human coronavirus SARS-CoV-2. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of V genes, and extensive activation of IgG and IgA subclasses without significant somatic mutation. We detect expansion of B cell clones as well as convergent antibodies with highly similar sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. A shared convergent B cell clonotype in SARS-CoV-2 infected patients was previously seen in patients with SARS. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and other zoonotic spillover coronaviruses.
DOI: 10.21203/rs.3.rs-27220/v1
PubMed: 32702737
PubMed Central: PMC7336706
Affiliations:
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Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Pinsky, Benjamin" sort="Pinsky, Benjamin" uniqKey="Pinsky B" first="Benjamin" last="Pinsky">Benjamin Pinsky</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32702737</idno><idno type="pmid">32702737</idno><idno type="doi">10.21203/rs.3.rs-27220/v1</idno><idno type="pmc">PMC7336706</idno><idno type="wicri:Area/Main/Corpus">000482</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000482</idno><idno type="wicri:Area/Main/Curation">000482</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000482</idno><idno type="wicri:Area/Main/Exploration">000482</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">B cell clonal expansion and convergent antibody responses to SARS-CoV-2.</title><author><name sortKey="Nielsen, Sandra C A" sort="Nielsen, Sandra C A" uniqKey="Nielsen S" first="Sandra C A" last="Nielsen">Sandra C A. Nielsen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Yang, Fan" sort="Yang, Fan" uniqKey="Yang F" first="Fan" last="Yang">Fan Yang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Hoh, Ramona A" sort="Hoh, Ramona A" uniqKey="Hoh R" first="Ramona A" last="Hoh">Ramona A. Hoh</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Jackson, Katherine J L" sort="Jackson, Katherine J L" uniqKey="Jackson K" first="Katherine J L" last="Jackson">Katherine J L. Jackson</name><affiliation><nlm:affiliation>Garvan Institute of Medical Research.</nlm:affiliation><wicri:noCountry code="no comma">Garvan Institute of Medical Research.</wicri:noCountry><wicri:noCountry code="no comma">Garvan Institute of Medical Research.</wicri:noCountry></affiliation></author><author><name sortKey="Roeltgen, Katharina" sort="Roeltgen, Katharina" uniqKey="Roeltgen K" first="Katharina" last="Roeltgen">Katharina Roeltgen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Lee, Ji Yeun" sort="Lee, Ji Yeun" uniqKey="Lee J" first="Ji-Yeun" last="Lee">Ji-Yeun Lee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Rustagi, Arjun" sort="Rustagi, Arjun" uniqKey="Rustagi A" first="Arjun" last="Rustagi">Arjun Rustagi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Rogers, Angela J" sort="Rogers, Angela J" uniqKey="Rogers A" first="Angela J" last="Rogers">Angela J. Rogers</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Powell, Abigail E" sort="Powell, Abigail E" uniqKey="Powell A" first="Abigail E" last="Powell">Abigail E. Powell</name><affiliation wicri:level="4"><nlm:affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Kim, Peter S" sort="Kim, Peter S" uniqKey="Kim P" first="Peter S" last="Kim">Peter S. Kim</name><affiliation wicri:level="4"><nlm:affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Pinsky, Benjamin" sort="Pinsky, Benjamin" uniqKey="Pinsky B" first="Benjamin" last="Pinsky">Benjamin Pinsky</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author><author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName><orgName type="university">Université Stanford</orgName></affiliation></author></analytic><series><title level="j">Research square</title><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During virus infection B cells are critical for the production of antibodies and protective immunity. Establishment of a diverse antibody repertoire occurs by rearrangement of germline DNA at the immunoglobulin heavy and light chain loci to encode the membrane-bound form of antibodies, the B cell antigen receptor. Little is known about the B cells and antigen receptors stimulated by the novel human coronavirus SARS-CoV-2. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of V genes, and extensive activation of IgG and IgA subclasses without significant somatic mutation. We detect expansion of B cell clones as well as convergent antibodies with highly similar sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. A shared convergent B cell clonotype in SARS-CoV-2 infected patients was previously seen in patients with SARS. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and other zoonotic spillover coronaviruses.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32702737</PMID><DateRevised><Year>2021</Year><Month>01</Month><Day>10</Day></DateRevised><Article PubModel="Electronic"><Journal><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>May</Month><Day>06</Day></PubDate></JournalIssue><Title>Research square</Title><ISOAbbreviation>Res Sq</ISOAbbreviation></Journal><ArticleTitle>B cell clonal expansion and convergent antibody responses to SARS-CoV-2.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">rs.3.rs-27220</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.21203/rs.3.rs-27220/v1</ELocationID><Abstract><AbstractText>During virus infection B cells are critical for the production of antibodies and protective immunity. Establishment of a diverse antibody repertoire occurs by rearrangement of germline DNA at the immunoglobulin heavy and light chain loci to encode the membrane-bound form of antibodies, the B cell antigen receptor. Little is known about the B cells and antigen receptors stimulated by the novel human coronavirus SARS-CoV-2. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of V genes, and extensive activation of IgG and IgA subclasses without significant somatic mutation. We detect expansion of B cell clones as well as convergent antibodies with highly similar sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. A shared convergent B cell clonotype in SARS-CoV-2 infected patients was previously seen in patients with SARS. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and other zoonotic spillover coronaviruses.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nielsen</LastName><ForeName>Sandra C A</ForeName><Initials>SCA</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Fan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoh</LastName><ForeName>Ramona A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>Katherine J L</ForeName><Initials>KJL</Initials><AffiliationInfo><Affiliation>Garvan Institute of Medical Research.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roeltgen</LastName><ForeName>Katharina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ji-Yeun</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rustagi</LastName><ForeName>Arjun</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rogers</LastName><ForeName>Angela J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Powell</LastName><ForeName>Abigail E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Peter S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Taia T</ForeName><Initials>TT</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pinsky</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blish</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boyd</LastName><ForeName>Scott D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>T32 AI007502</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K23 HL125663</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI127877</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 AI111825</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI139119</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI130398</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D000076942">Preprint</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Res Sq</MedlineTA><NlmUniqueID>101768035</NlmUniqueID></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="UpdateIn"><RefSource>Cell Host Microbe. 2020 Sep 3;:</RefSource><PMID Version="1">32941787</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">B cells</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">antigen receptors</Keyword></KeywordList><CoiStatement>Competing interests: The authors declare no competing interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32702737</ArticleId><ArticleId IdType="doi">10.21203/rs.3.rs-27220/v1</ArticleId><ArticleId IdType="pmc">PMC7336706</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Bioinformatics. 2012 Dec 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Jackson</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Nielsen, Sandra C A" sort="Nielsen, Sandra C A" uniqKey="Nielsen S" first="Sandra C A" last="Nielsen">Sandra C A. Nielsen</name></region><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name><name sortKey="Hoh, Ramona A" sort="Hoh, Ramona A" uniqKey="Hoh R" first="Ramona A" last="Hoh">Ramona A. Hoh</name><name sortKey="Kim, Peter S" sort="Kim, Peter S" uniqKey="Kim P" first="Peter S" last="Kim">Peter S. Kim</name><name sortKey="Lee, Ji Yeun" sort="Lee, Ji Yeun" uniqKey="Lee J" first="Ji-Yeun" last="Lee">Ji-Yeun Lee</name><name sortKey="Pinsky, Benjamin" sort="Pinsky, Benjamin" uniqKey="Pinsky B" first="Benjamin" last="Pinsky">Benjamin Pinsky</name><name sortKey="Powell, Abigail E" sort="Powell, Abigail E" uniqKey="Powell A" first="Abigail E" last="Powell">Abigail E. Powell</name><name sortKey="Roeltgen, Katharina" sort="Roeltgen, Katharina" uniqKey="Roeltgen K" first="Katharina" last="Roeltgen">Katharina Roeltgen</name><name sortKey="Rogers, Angela J" sort="Rogers, Angela J" uniqKey="Rogers A" first="Angela J" last="Rogers">Angela J. Rogers</name><name sortKey="Rustagi, Arjun" sort="Rustagi, Arjun" uniqKey="Rustagi A" first="Arjun" last="Rustagi">Arjun Rustagi</name><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name><name sortKey="Yang, Fan" sort="Yang, Fan" uniqKey="Yang F" first="Fan" last="Yang">Fan Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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